Synthesis, Characterization, and Pharmacokinetic Studies of Thiazolidine-2,4-Dione Derivatives

Various derivatives of thiazolidine-2,4-dione (C1–C5) were designed and synthesized by chemical reaction with 4-nitrobenzaldehyde using Knoevenagel conditions which results in the reduction nitro group to amine further modification target compounds. The structures all 2,4-thiazolidinedione have been elucidated 1H 13C NMR spectroscopy. These compounds characterized silico ADME (absorption, distribution, metabolism, excretion) studies. pharmacokinetic properties assessed SwissADME software. assessment reveals that (C1 C5) 5 7 rotatable bonds. Lipophilicity water solubility showed C1, C2, C4 are soluble except for C3 C5 moderately soluble. All high GI absorption C3. None blood-brain barrier permeant. Drug metabolism TZDs was identified as an inhibitor CYP2C9 CYP1A2 CYP2C19. likeness indicate C1 has only one violation Ghose rule while violations Egan rules. studies revealed inability pass can be vitro vivo antihyperglycemic activity. This study will contribute providing improved profile decreased toxicity.